Calcium Fructoborate

Global Calcium is one of the leading manufacturers and exporters of Calcium Fructoborate CAS no. 250141-42-5, Mineral Actives . We support the customers with exhaustive documentation. As a USDMF & EU-GMP certified global company and an established hallmark for pharmaceutical standards, Global Calcium has stood the test of time since its inception in 1979.

As manufacturer of Calcium Fructoborate we hereby state the following facts about the drug:

The chemical status of boron in nutrition is very important. In plants, boron is found in the form of sugar esters and there are studies that show that its assimilation is very much connected to the chemistry of boron sugar esters. The boron sugar esters are the best chemical form for assimilation into cells. In researching various boron compounds, scientists discovered a plant form of boron known as calcium fructoborate (CF) that is a complex of calcium, fructose, and boron found naturally in fruits, vegetables, and other food. This form of boron is not only safe, but also bioavailable compared with other commercial forms of boron. CF is a natural product that can be very efficiently used as a boron food supplement in prevention and adjuvant treatment of osteoporosis and osteoarthritis. It is a sugar-borate ester which is the most scientifically studied boron-based dietary supplement. It is known that at the cell pH of 7.4, boron (B) is connected with fructose only as free boric acid and fructoborate esters and not as anion borate (this is because fructoborates pK_a is 4.16). Overall, there are scientific data about a more general function for B, where B cross-links glycoproteins in cell membranes. Subsequently, the most probable action mechanism of CF may be the chemical bonding of fructoborate to specific cytokines glycoproteic receptors at the surface of the cellular membrane. This may be happening since the fructoborate pK_a (4.16) is lower than the cellular pH (7.4), compared with the boric acid whose pK_a (9.24) is higher than the cellular pH. Consequently, fructoborate has a better interaction capacity with glycoproteins versus that of the boric acid/borate. Furthermore, the free boric acid generated by hydrolysis of the fructoborate complex was recently shown to crystallize in the hexagonal system rather than in the triclinic system as compared to the regular boric acid. These different ways of crystallization may influence toxicity and biological activity of the free boric acid.

 

Therapeutic uses and effectiveness:

 

Osteoporosis is a disease that affects a large group of people at different ages, both men and women, and it takes a long treatment, with expensive materials and social costs. Through its complications, the disease produces Osteoporosis is a disease that affects a large group of people at different ages, both men and women, and it takes a long treatment, with expensive

materials and social costs. Through its complications, the disease produces

• Osteoporosis is a disease that affects a large group of people at different ages, both men and women, and it takes a long treatment, with expensive materials and social costs. CF may influence bone density in vitamin D-deficient animals. Boron has been shown to improve bone strength characteristics in rats and pigs. Results show a dose-dependent increase in bone density as measured by total ash mass
• CF also has been found to counteract the harmful effects of dietary vitamin D deficiency
• A correlation between vitamin D3 deficiency and an increased risk for cardiovascular attacks and influence of vitamin D3 on bone health and articulations has been demonstrated. Several studies have shown that CF was absorbed from the gastrointestinal tract to the blood-stream in an intact form and time-dependent manner. It was shown that CF can be detected intact in blood following oral administration. If this is the case, the biological effects of CF observed so far could be due to its activity in an intact form

 

When compared to other studies that treated osteoarthritis using glucosamine and chondoitrin sulfate, CF has been much better than these substances, both as an anti-inflammatory agent and a painkiller. These find-ings highlight other benefits of boron in biological systems. It serves as an anti-inflammatory substance through inhibition of the oxidative burst by scavenging cells (leukocytes) and excessive activity by neutrophils, white cells that scavenge debris and invaders outside of the circulatory system. CF and boron also improve free radical scavenging by raising the level of

 

• Few studies have shown when osteoarthritis is treated using glucosamine and chondoitrin sulfate, CF has been much better than these substances, both as an anti-inflammatory agent and a painkiller. These findings highlight other benefits of boron in biological systems. It serves as an anti-infiammatory substance through inhibition of the oxidative burst by scavenging cells (leukocytes) and excessive activity by neutrophils, white cells that scavenge debris and invaders outside of the circulatory system. CF has antioxidant activity that could have clinical significance in protecting skin cells from oxidation-induced injury
• Both boric acid and CF inhibited the growth of breast cancer cells, while only CF induced apoptosis

Global Calcium is a leading manufacturer of this drug. We manufacture this pharmaceutical drug and make it available to domestic and overseas market