Global Calcium is one of the leading manufacturers and exporters of
Calcium Threonate CAS no. 70753-61-6, Mineral Actives
. We support the customers with exhaustive documentation. As a USDMF & EU-GMP certified global company and an established hallmark for pharmaceutical standards, Global Calcium has stood the test of time since its inception in 1979.
As manufacturer of Calcium Threonate we hereby state the following facts about the drug:
Calcium threonate is a calcium salt of threnoic acid and a novel drug developed for the treatment of osteoporosis and as a calcium supplement. It is found in dietary supplements as a source of L-threonate used in the treatment of calcium deficiency and the prevention of osteoporosis. The most common form is calcium L-threonate, or (2R,3S)-2,3,4-trihydroxy butyric acid calcium. L-threonate is an active metabolite of vitamin C that mediates a stimulatory action on vitamin C uptake. Therapeutic efficacy of calcium threonate in reducing was studied and investigated due to the hypothesis that it may play a role in the mineralization process through its positive action on vitamin C.
Human studies demonstrate that calcium from calcium L-threonate is absorbed and the presence of threonic acid in human urine has been identified.
Mechanism of action: Once dissociated to calcium and L-theronic acid, L-threonic acid exhibits significant stimulatory action on vitamin C uptake and prolongs the retention of vitamin C in human T-lymphoma cells. Vitamin C is a marker for osteoblast formation and has been shown to stimulate procollagen and enhance collagen synthesis. Via stimulation of vitamin C uptake, L-threonic acid acts as a metabolite that influences the mineralization process.
Effectiveness and other related information:
- In a preclinical study, calcium L-theronate inhibited the bone resorption of osteoclasts in vitro
- Animal studies indicate that calcium from calcium L-threonate is absorbed. The bioavailability of calcium from this source was comparable to or higher than from other sources of calcium
- In a study, the pharmacokinetics of calcium L-threonate after single or multiple oral administrations and its safety profile in healthy Chinese volunteers was evaluated. Calcium L-threonate was well tolerated in healthy Chinese subjects, with no pattern of dose-related adverse events. L-threonate was absorbed rapidly, and its absorption was enhanced by food intake. No systemic accumulation appeared after repeated administrations.
Global Calcium is a leading manufacturer of this drug. We manufacture this pharmaceutical drug and make it available to domestic and overseas market