Global Calcium is one of the leading manufacturers and exporters of
Entacapone CAS no. 130929-57-6, API, (Active Pharmaceutical Ingredient). We support the customers with exhaustive documentation. As a USDMF & EU-GMP certified global company and an established hallmark for pharmaceutical standards, Global Calcium has stood the test of time since its inception in 1979.
As manufacturer of Entacapone we hereby state the following facts about the drug:
Entacapone API is the active pharmaceutical ingredient at the heart of a class of drugs designed to manage the symptoms of Parkinson's disease. Parkinson's is a neurodegenerative disorder affecting millions worldwide. Our API, Entacapone, offers an effective approach to enhance the quality of life for patients living with this condition.
Mechanism of action
The mechanism of action of entacapone is believed to be through its ability to inhibit COMT in peripheral tissues, altering the plasma pharmacokinetics of levodopa. When entacapone is given in conjunction with levodopa and an aromatic amino acid decarboxylase inhibitor, such as carbidopa, plasma levels of levodopa are greater and more sustained than after administration of levodopa and an aromatic amino acid decarboxylase inhibitor alone. It is believed that at a given frequency of levodopa administration, these more sustained plasma levels of levodopa result in more constant dopaminergic stimulation in the brain, leading to a greater reduction in the manifestations of parkinsonian syndrome.
Global Calcium is a leading manufacturer of this drug. We manufacture this pharmaceutical drug and make it available to domestic and overseas market